2024 2-naphthylamine+toxicity - blag0y.ru
WEBDec 21, 2021 · 2-Naphthylamine is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans. Cancer Studies in Humans. Epidemiological studies have shown that occupational exposure to 2-naphthylamine, either alone or present as an impurity in other compounds, causes cancer of the urinary bladder.WEB2-Naphthylamine is one of two isomeric aminonaphthalenes, compounds with the formula C 10 H 7 NH 2. It is a colorless solid, but samples take on a reddish color in air because of oxidation. It was formerly used to make azo dyes, but it is a known carcinogen and has largely been replaced by less toxic compounds.WEBThe general population can be exposed to 2-naphthylamine through tobacco smoke and other fumes containing 2-naphthylamine, or reportedly when in contact with dyes and hair dyes contaminated with 2-naphthylamine [The Working Group could not find evidence of current contamination of these consumer products].WEBMar 30, 2020 · Based on literature data, the effects of 2-NA toxicity in sub-chronic and chronic exposure include contact dermatitis, chronic cystitis and bladder cancer. The authors have concluded that it is recommended to determine the occupational exposure limit which will allow preparing the exposure assessment of people at work.WEBThe acute toxicity of 2-Naphthylamine in humans causes methemoglobinemia, hemorrhagic cystitis, as well as cerebral hypoxia and other organs. Moreover, chronic exposure to the compound has been linked to bladder cancer and it can cause dysuria, hematuria, and hemorrhagic cystitis.WEBHuman lung chromosomes contain high levels of arylamine peroxidase activity which readily activates ABP, benzidine, 4,4′-methylenebis(2-chloroaniline) (MOCA), 2-amino-fluorene (AF) and 2-naphthylamine as measured by DNA-adduct formation (Culp et al., 1997).WEBDescription. Beta-naphthylamine appears as a white to reddish colored solid in the form of flakes. Slightly soluble in hot water and denser than water. Toxic by ingestion, inhalation and skin absorption. Used to make dyes and agricultural chemicals. CAMEO Chemicals. 2-naphthylamine is a naphthylamine carrying the amino group at position 2.WEBlowest published toxic dose: 1300 mg/kg/13W- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's diseaseWEBOccupational and tobacco exposure to aromatic amines (AAs) including 4-aminobiphenyl (4-ABP) and 2-naphthylamine (2-NA) are associated with bladder cancer (BC) risk. Several epidemiological studies have also reported a possible role for structurally related heterocyclic aromatic amines (HAAs) formed ….WEB2-Naphthylamine / poisoning* 2-Naphthylamine / toxicity Animals Carcinogenicity Tests Carcinogens, Environmental / poisoning* Carcinogens, Environmental / toxicity Government Regulation Guidelines as Topic ...WEBhuman volunteers showed that up to 0.03% of a single 10-mg dose of N-phenyl-2-naphthylamine is converted internally to 2-naphthylamine (IARC, 1978). More recently, it has been estimated that a maximum of 1% of total N-phenyl-2-naphthylamine uptake can be metabolized into 2-NA (Weiss et al., 2007).WEBThe dicyclic arylamine 2-naphthylamine (Figure 25) has demonstrated carcinogenicity in several species, including humans. On the other hand, 1-naphthylamine has not revealed carcinogenic potential in experimentation, but the process for its production can generate 2-naphthylamine and other possibly carcinogenic aromatic amines.WEBFeb 24, 2020 · Based on literature data, the effects of 2-NA toxicity in sub-chronic and chronic exposure include contact dermatitis, chronic cystitis and bladder cancer.WEBFeb 24, 2020 · Europe PMC is an archive of life sciences journal literature.WEB2-NA is a toxic substance when swallowed. In the available literature, only 2 LD50 values were described for 2 routes of exposure: intragastric and in-traperitoneal. The median value of lethal doses for rats after oral administration is 727 mg/kg, and after intra-peritoneal exposure for mice – 200 mg/kg [9,10]. Tox-WEBOur findings suggest that BNA N-acetylation and toxicity is modified by NAT2 polymorphism. Furthermore, they confirm heterogeneity among slow acetylator alleles for BNA metabolism and toxicity supporting differential risk for …WEBThe toxic interaction between 2-naphthylamine (2-NA) and herring sperm deoxyribonucleic acid (hs-DNA) has been thoroughly investigated by UV absorption, fluorescence, and circular dichroism (CD) spectroscopic methods.WEBApr 26, 2013 · The toxic interaction between 2-naphthylamine (2-NA) and herring sperm deoxyribonucleic acid (hs-DNA) has been thoroughly investigated by UV absorption, fluorescence, and circular dichroism (CD) spectroscopic methods.WEBJun 1, 2017 · N-Phenyl-1-naphthylamine (P 1 NA) and N-Phenyl-2-naphthylamine (P 2 NA) are both widely used as antioxidant and plant secondary metabolites. In this study, growth, esterase, photosynthetic activity and cell membrane integrity were used as biomarkers to compare biotoxicity of P 1 NA and P 2 NA on Microcystis aeruginosa.WEBThe mechanism of interaction between bovine serum albumin (BSA) and 2-naphthylamine (2-NA) in aqueous solution was investigated by fluorescence spectroscopy, circular dichroism (CD) spectra, and UV-vis spectroscopy.WEBMar 21, 2019 · Additionally, our results indicated that the toxicity target at low concentrations of N-phenyl-2-naphthylamine was at each step of electron transport between Q A − and the Cyt b6/f complex; whereas, the reduction of Q A was the potential target at high concentrations.WEBOct 1, 2006 · N-phenyl-2-naphthylamine, a sediment contaminant previously identified as a major toxicant of site-specific importance was investigated for its mode of toxic action. From short-term bioassays with daphnids, fish eggs, bacteria, and algae it appears that this compound has specific phytotoxic properti ….
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